The meme originates from two different sources: a TV show called Man vs Wild and an unofficial motto from the United States Marine Corp. Bear Grylls, host of Man vs Wild, is the man pictured in the meme. The meme ironically uses the Marines’ motto to point out situations that don’t require such seriousness.
Generally speaking, the meme is a metaphor where one remembers their parents and straightens their crown as an act to prepare to take on an impending challenge. There are many takes on this metaphor that range from religious to personally sentimental. In every case, the meme is intended to be inspirational.
The man of culture meme usually comes in two forms. It can be a self-contained joke with words used to set up and deliver the punchline. It can also be used as a response to a comment, in which case it can be taken literally, ironically, or even sarcastically, requiring context clues to decipher the true intent.
Most directly, the phrase is supposed to be read as, “There’s no place like home.”
This is a reference to IP naming conventions and the localhost (also known as the home network), which is typically given the default address of 127.0.0.1.
It’s basically a pun that plays into this basic bit of networking knowledge.